Researchers from the Human Brain Project used a multi-scale approach, combining various imaging methods to understand the human brain’s connectome, or the interconnected structure, from the molecular to the macro level. They used 3D Polarized Light Imaging to visualize nerve fibers and placed their findings within the Julich Brain Atlas to spatially reference the data, revealing new insights about the brain’s organization and functioning.
To understand how our brain works, there is no getting around investigating how different brain regions are connected with each other by nerve fibers. In the journal Science, researchers of the Human Brain Project (HBP) review the current state of the field, provide insights on how the brain’s connectome is structured on different spatial scales – from the molecular and cellular to the macro level – and evaluate existing methods and future requirements for understanding the connectome’s complex organization.
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