Do aliens exist? Almost certainly. The Universe is vast and ancient, and our corner of it is not particularly special. If life emerged here, it probably did elsewhere.
Keep in mind this is a super broad assumption. A single instance of fossilized archaebacteria-like organisms five superclusters away would be all it takes to say, "Yes, there are aliens!" …if we could find them somehow.
Until we can send paleontologists to other galaxies, the best way to search for aliens is to stay at home and look for "techno-signatures."
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